Threadworms, whipworms, roundworms, and hookworms are all treated with mebendazole. Cimetidine, according to preliminary research, inhibits mebendazole metabolism and may cause an increase in plasma levels.
Mebendazole is a synthetic broad-spectrum anthelmintic that kills most nematodes as well as some other worms. Mebendazole is primarily used to treat nematode infections in the intestine.Mebendazole prevents the worms from forming microtubules, resulting in glucose depletion. After oral administration, the Gl tract absorbs around 2-10% of the oral dose, and peak plasma concentration occurs between 30 minutes to 7 hours. Mebendazole has a strong affinity for plasma proteins. The half-life of elimination is 2.8 to 9 hours.
